abstract：:Nucleostemin (NS), a member of a family of nucleolar GTP-binding proteins, is highly expressed in proliferating cells such as stem and cancer cells and is involved in the control of cell cycle progression. Both depletion and overexpression of NS result in stabilization of the tumor suppressor p53 protein in vitro. Alt...

journal_title：Developmental biology

authors： Paridaen JT,Janson E,Utami KH,Pereboom TC,Essers PB,van Rooijen C,Zivkovic D,MacInnes AW

更新日期：2011-07-15 00:00:00

abstract：:Spinal cord regenerative ability is lost with development, but the mechanisms underlying this loss are still poorly understood. In chick embryos, effective regeneration does not occur after E13, when spinal cord injury induces extensive apoptotic response and tissue damage. As initial experiments showed that treatment...

journal_title：Developmental biology

authors： Lange S,Gögel S,Leung KY,Vernay B,Nicholas AP,Causey CP,Thompson PR,Greene ND,Ferretti P

更新日期：2011-07-15 00:00:00

abstract：:Cells anchor to substrates by binding to extracellular matrix (ECM). In addition to this anchoring function however, cell-ECM binding is a mechanism for cells to sense their surroundings and to communicate and coordinate behaviour amongst themselves. Several ECM molecules and their receptors play essential roles in mu...

journal_title：Developmental biology

authors： Thorsteinsdóttir S,Deries M,Cachaço AS,Bajanca F

更新日期：2011-06-15 00:00:00

abstract：:An understanding of heart development is critical in any systems biology approach to cardiovascular disease. The interpretation of data generated from high-throughput technologies (such as microarray and proteomics) is also essential to this approach. However, characterizing the role of genes in the processes underlyi...

journal_title：Developmental biology

authors： Khodiyar VK,Hill DP,Howe D,Berardini TZ,Tweedie S,Talmud PJ,Breckenridge R,Bhattarcharya S,Riley P,Scambler P,Lovering RC

更新日期：2011-06-01 00:00:00

abstract：:We present a genetic map for Xenopus tropicalis, consisting of 2886 Simple Sequence Length Polymorphism (SSLP) markers. Using a bioinformatics-based strategy, we identified unique SSLPs within the X. tropicalis genome. Scaffolds from X. tropicalis genome assembly 2.0 (JGI) were scanned for Simple Sequence Repeats (SSR...

journal_title：Developmental biology

authors： Wells DE,Gutierrez L,Xu Z,Krylov V,Macha J,Blankenburg KP,Hitchens M,Bellot LJ,Spivey M,Stemple DL,Kowis A,Ye Y,Pasternak S,Owen J,Tran T,Slavikova R,Tumova L,Tlapakova T,Seifertova E,Scherer SE,Sater AK

更新日期：2011-06-01 00:00:00

abstract：:The NCK adaptor proteins are composed entirely of SH3 and SH2 domains and serve as protein interaction bridges for several receptors during signal transduction events. Here we report the molecular and genetic analysis of the Caenorhabditis elegans nck-1 gene. C. elegans nck-1 encodes two isoforms: NCK-1A and a shorter...

journal_title：Developmental biology

authors： Mohamed AM,Chin-Sang ID

更新日期：2011-06-01 00:00:00

abstract：:One of the earliest steps in embryonic development is the establishment of the future body axes. Morphological and molecular data place the Ambulacraria (echinoderms and hemichordates) within the Deuterostomia and as the sister taxon to chordates. Extensive work over the last decades in echinoid (sea urchins) echinode...

journal_title：Developmental biology

authors： Röttinger E,Martindale MQ

更新日期：2011-06-01 00:00:00

abstract：:The Ci-Dll-B gene is an early regulator of ectodermal development in the ascidian Ciona intestinalis (Imai et al., 2006). Ci-Dll-B is located in a convergently transcribed bigene cluster with a tandem duplicate, Ci-Dll-A. This clustered genomic arrangement is the same as those of the homologous vertebrate Dlx genes, w...

journal_title：Developmental biology

authors： Irvine SQ,Vierra DA,Millette BJ,Blanchette MD,Holbert RE

更新日期：2011-05-15 00:00:00

abstract：:In the Drosophila ventral nerve cord, the three pairs of Capability neuropeptide-expressing Va neurons are exclusively found in the second, third and fourth abdominal segments (A2-A4). To address the underlying mechanisms behind such segment-specific cell specification, we followed the developmental specification of t...

journal_title：Developmental biology

authors： Suska A,Miguel-Aliaga I,Thor S

更新日期：2011-05-01 00:00:00

abstract：:The mammalian Cul4 genes, Cul4A and Cul4B, encode the scaffold components of the cullin-based E3 ubiquitin ligases. The two Cul4 genes are functionally redundant. Recent study indicated that mice expressing a truncated CUL4A that fails to interact with its functional partner ROC1 exhibit no developmental phenotype. We...

journal_title：Developmental biology

authors： Kopanja D,Roy N,Stoyanova T,Hess RA,Bagchi S,Raychaudhuri P

更新日期：2011-04-15 00:00:00

abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

journal_title：Developmental biology

authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

更新日期：2011-04-15 00:00:00

abstract：:Organismal growth and body size are influenced by both genetic and environmental factors. We have utilized the strong molecular genetic techniques available in the nematode Caenorhabditis elegans to identify genetic determinants of body size. In C. elegans, DBL-1, a member of the conserved family of secreted growth fa...

journal_title：Developmental biology

authors： Fernando T,Flibotte S,Xiong S,Yin J,Yzeiraj E,Moerman DG,Meléndez A,Savage-Dunn C

更新日期：2011-04-01 00:00:00

abstract：:The nematode Caenorhabditis elegans has retained a rudimentary Hedgehog (Hh) signalling pathway; Hh and Smoothened (Smo) homologs are absent, but two highly related Patched gene homologs, ptc-1 and ptc-3, and 24 ptc-related (ptr) genes are present. We previously showed that ptc-1 is essential for germ line cytokinesis...

journal_title：Developmental biology

authors： Soloviev A,Gallagher J,Marnef A,Kuwabara PE

更新日期：2011-03-15 00:00:00

abstract：:The first step in the development of the Drosophila optic medullar primordia is the expansion of symmetrically dividing neuroepithelial cells (NEs); this step is then followed by the appearance of asymmetrically dividing neuroblasts (NBs). However, the mechanisms responsible for the change from NEs to NBs remain uncle...

journal_title：Developmental biology

authors： Orihara-Ono M,Toriya M,Nakao K,Okano H

更新日期：2011-03-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) regulate a number of major developmental processes, but their roles in synovial joint formation remain unknown. Here we created conditional mouse embryo mutants lacking Ext1 in developing joints by mating Ext1(f/f) and Gdf5-Cre mice. Ext1 encodes a subunit of the Ext1/Ext2 Golgi-a...

journal_title：Developmental biology

authors： Mundy C,Yasuda T,Kinumatsu T,Yamaguchi Y,Iwamoto M,Enomoto-Iwamoto M,Koyama E,Pacifici M

更新日期：2011-03-01 00:00:00

abstract：:DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack DNA synthesis in postembryonic somatic cell lineages, while entry into mitosis continues. These mutants grow slowly and either die...

journal_title：Developmental biology

authors： Korzelius J,The I,Ruijtenberg S,Portegijs V,Xu H,Horvitz HR,van den Heuvel S

更新日期：2011-02-15 00:00:00

abstract：:In Xenopus gastrulation, the involuting mesodermal and non-involuting ectodermal cells remain separated from each other, undergoing convergent extension. Here, we show that Eph-ephrin signaling is crucial for the tissue separation and convergence during gastrulation. The loss of EphA4 function results in aberrant gast...

journal_title：Developmental biology

authors： Park EC,Cho GS,Kim GH,Choi SC,Han JK

更新日期：2011-02-15 00:00:00

abstract：:Caenorhabditis elegans embryonic elongation depends on both epidermal and muscle cells. The hemidesmosome-like junctions, commonly called fibrous organelles (FOs), that attach the epidermis to the extracellular matrix ensure muscle anchoring to the cuticular exoskeleton and play an essential role during elongation. To...

journal_title：Developmental biology

authors： Hetherington S,Gally C,Fritz JA,Polanowska J,Reboul J,Schwab Y,Zahreddine H,Behm C,Labouesse M

更新日期：2011-02-15 00:00:00

abstract：:Cranial placodes are specialized ectodermal regions in the developing vertebrate head that give rise to both neural and non-neural cell types of the neuroendocrine system and the sense organs of the visual, olfactory and acoustic systems. The cranial placodes develop from a panplacodal region which is specifically mar...

journal_title：Developmental biology

authors： Posnien N,Koniszewski N,Bucher G

更新日期：2011-02-01 00:00:00

abstract：:Gnathostomes (jawed vertebrates) possess skeletal muscles with unique functional and developmental features that are absent from cyclostomes-i.e., lamprey and hagfish. These gnathostome-specific traits include the epaxial and hypaxial division of myotomes, paired fin/limb muscles, shoulder girdle muscles, and the musc...

journal_title：Developmental biology

authors： Kusakabe R,Kuraku S,Kuratani S

更新日期：2011-02-01 00:00:00

abstract：:Oral-facial-digital type I (OFDI) syndrome is an X-linked male lethal developmental disorder. It is ascribed to ciliary dysfunction and characterized by malformation of the face, oral cavity, and digits. Conditional inactivation using different Cre lines allowed us to study the role of the Ofd1 transcript in limb deve...

journal_title：Developmental biology

authors： Bimonte S,De Angelis A,Quagliata L,Giusti F,Tammaro R,Dallai R,Ascenzi MG,Diez-Roux G,Franco B

更新日期：2011-01-15 00:00:00

abstract：:Extensive elongation of lens fiber cells is a central feature of lens morphogenesis. Our study investigates the role of N-cadherin junctions in this process in vivo. We investigate both the molecular players involved in N-cadherin junctional maturation and the subsequent function of these junctions as epicenters for t...

journal_title：Developmental biology

authors： Leonard M,Zhang L,Zhai N,Cader A,Chan Y,Nowak RB,Fowler VM,Menko AS

更新日期：2011-01-15 00:00:00

abstract：:Morphogenesis is a fascinating but complex and incompletely understood developmental process. The sensory lateral line system consists of only a few hundred cells and is experimentally accessible making it an excellent model system to interrogate the cellular and molecular mechanisms underlying segmental morphogenesis...

journal_title：Developmental biology

authors： Aman A,Nguyen M,Piotrowski T

更新日期：2011-01-15 00:00:00

abstract：:The Id1 and Id3 genes play major roles during cardiac development, despite their expression being confined to non-myocardial layers (endocardium-endothelium-epicardium). We previously described that Id1Id3 double knockout (dKO) mouse embryos die at mid-gestation from multiple cardiac defects, but early lethality precl...

journal_title：Developmental biology

authors： Zhao Q,Beck AJ,Vitale JM,Schneider JS,Gao S,Chang C,Elson G,Leibovich SJ,Park JY,Tian B,Nam HS,Fraidenraich D

更新日期：2011-01-01 00:00:00

abstract：:The Notch signaling pathway controls cell fate choices at multiple steps during cell lineage progression. To produce the cell fate choice appropriate for a particular stage in the cell lineage, Notch signaling needs to interpret the cell context information for each stage and convert it into the appropriate cell fate ...

journal_title：Developmental biology

authors： Das D,Lanner F,Main H,Andersson ER,Bergmann O,Sahlgren C,Heldring N,Hermanson O,Hansson EM,Lendahl U

更新日期：2010-12-15 00:00:00

abstract：:To analyse cell migration and the differentiation potential of migratory stem cells in Hydractinia, we generated animals with an eGFP reporter gene stably expressed and transmitted via the germline. The transgene was placed under the control of two different actin promoters and the promoter of elongation factor-1α. On...

journal_title：Developmental biology

authors： Künzel T,Heiermann R,Frank U,Müller W,Tilmann W,Bause M,Nonn A,Helling M,Schwarz RS,Plickert G

更新日期：2010-12-01 00:00:00

abstract：:The categorical data set is an important data class in experimental biology and contains data separable into several mutually exclusive categories. Unlike measurement of a continuous variable, categorical data cannot be analyzed with methods such as the Student's t-test. Thus, these data require a different method of ...

journal_title：Developmental biology

authors： Xu B,Feng X,Burdine RD

更新日期：2010-12-01 00:00:00

abstract：:Embryonic kidney development begins with the outgrowth of the ureteric bud (UB) from the Wolffian duct (WD) into the adjacent metanephric mesenchyme (MM). Both a GDNF-dependent and GDNF-independent (Maeshima et al., 2007) pathway have been identified. In vivo and in vitro, the GDNF-dependent pathway is inhibited by BM...

journal_title：Developmental biology

authors： Tee JB,Choi Y,Shah MM,Dnyanmote A,Sweeney DE,Gallegos TF,Johkura K,Ito C,Bush KT,Nigam SK

更新日期：2010-11-15 00:00:00

abstract：:The processes of myelination remain incompletely understood but are of profound biomedical importance owing to the several dysmyelinating and demyelinating disorders known in humans. Here, we analyze the zebrafish puma mutant, isolated originally for pigment pattern defects limited to the adult stage. We show that pum...

journal_title：Developmental biology

authors： Larson TA,Gordon TN,Lau HE,Parichy DM

更新日期：2010-10-15 00:00:00

abstract：:Fibronectin (Fn) plays an important part in the branching morphogenesis of salivary gland, lung, and kidney. Here, we examine the effect of the conditional knockout of Fn in the mammary epithelium [Fn(MEp-/-)] on postnatal mammary gland development, using Cre-loxP-mediated gene knockout technology. Our data show that ...

journal_title：Developmental biology

authors： Liu K,Cheng L,Flesken-Nikitin A,Huang L,Nikitin AY,Pauli BU

更新日期：2010-10-01 00:00:00

abstract：:Thrombospondin type 1 repeat (TSR) superfamily members regulate diverse biological activities ranging from cell motility to inhibition of angiogenesis. In this study, we verified that mouse protein O-fucosyltransferase-2 (POFUT2) specifically adds O-fucose to TSRs. Using two Pofut2 gene-trap lines, we demonstrated tha...

journal_title：Developmental biology

authors： Du J,Takeuchi H,Leonhard-Melief C,Shroyer KR,Dlugosz M,Haltiwanger RS,Holdener BC

更新日期：2010-10-01 00:00:00

abstract：:Controlled organismal growth to an appropriate adult size requires a regulated balance between nutrient resources, feeding behavior and growth rate. Defects can result in decreased survival and/or reproductive capability. Since Drosophila adults do not grow larger after eclosion, timing of feeding cessation during the...

journal_title：Developmental biology

authors： Wegman LJ,Ainsley JA,Johnson WA

更新日期：2010-09-15 00:00:00

abstract：:Metazoan development involves a myriad of dynamic cellular processes that require cytoskeletal function. Nonmuscle myosin II plays essential roles in embryonic development; however, knowledge of its role in post-embryonic development, even in model organisms such as Drosophila melanogaster, is only recently being reve...

journal_title：Developmental biology

authors： Franke JD,Montague RA,Kiehart DP

更新日期：2010-09-15 00:00:00

abstract：:Vertebrate hematopoiesis is characterized by two evolutionally conserved phases of development, i.e., primitive hematopoiesis, which is a transient phenomenon in the early embryo, and definitive hematopoiesis, which takes place in the later stages. Beni fuji (bef) was originally isolated as a medaka mutant that has an...

journal_title：Developmental biology

authors： Moriyama A,Inohaya K,Maruyama K,Kudo A

更新日期：2010-09-15 00:00:00

abstract：:The colonial tunicate Botrylloides leachi can regenerate functional adults from minute vasculature fragments, in a poorly understood phenomenon termed Whole Body Regeneration (WBR). Using Piwi expression (Bl-Piwi), blood cell labeling and electron microscopy, we show that WBR develops through activation, mobilization ...

journal_title：Developmental biology

authors： Rinkevich Y,Rosner A,Rabinowitz C,Lapidot Z,Moiseeva E,Rinkevich B

更新日期：2010-09-01 00:00:00

abstract：:Nociceptive neurons innervate the skin with complex dendritic arbors that respond to pain-evoking stimuli such as harsh mechanical force or extreme temperatures. Here we describe the structure and development of a model nociceptor, the PVD neuron of C. elegans, and identify transcription factors that control morphogen...

journal_title：Developmental biology

authors： Smith CJ,Watson JD,Spencer WC,O'Brien T,Cha B,Albeg A,Treinin M,Miller DM 3rd

更新日期：2010-09-01 00:00:00

abstract：:Hox genes of the Abdominal-B (Abd-B) class regulate gonadal development in diverse metazoans. Here we have investigated the role of the Abd-B homolog egl-5 in C. elegans gonadal development. Previous work showed that egl-5 is required male-specifically in the gonad and that mutant gonads are highly dysgenic and possib...

journal_title：Developmental biology

authors： Kalis AK,Murphy MW,Zarkower D

更新日期：2010-08-15 00:00:00

abstract：:Gastrulation is the first major morphogenetic movement in development and requires dynamic regulation of cell adhesion and the cytoskeleton. Caenorhabditis elegans gastrulation begins with the migration of the two endodermal precursors, Ea and Ep, from the surface of the embryo into the interior. Ea/Ep migration provi...

journal_title：Developmental biology

authors： Grana TM,Cox EA,Lynch AM,Hardin J

更新日期：2010-08-15 00:00:00

abstract：:The homeobox gene sine oculis (so) is required for the development of the entire visual system in Drosophila, which includes the compound eyes, the ocelli, the optic lobe of the brain and the Bolwig's organ. During ocelli development, so expression labels, together with eyes absent (eya), the emergence of the ocellar ...

journal_title：Developmental biology

authors： Blanco J,Pauli T,Seimiya M,Udolph G,Gehring WJ

更新日期：2010-08-15 00:00:00

abstract：:The outstanding migration and differentiation capacities of neural crest cells (NCCs) have fascinated scientists since Wilhelm His described this cell population in 1868. Today, after intense research using vertebrate model organisms, we have gained considerable knowledge regarding the origin, migration and differenti...

journal_title：Developmental biology

authors： Betters E,Liu Y,Kjaeldgaard A,Sundström E,García-Castro MI

更新日期：2010-08-15 00:00:00